Treatment of leprosy with thiosemicarbazone and DDS; a comparative series among Australian aborigines.
نویسنده
چکیده
The introduction of the complex sulfone derivatives marked a considerable advance in the treatment of leprosy, but it also meant a period of some confusion while the various kinds of derivatives were on trial. The period of trial has, in the main, ended by the acceptance of the majority of the parent substance, DDS, as the drug of choice. It is noted, however, that at the BELRA conference on sulfone therapy (1) there was support for sulphetrone given parenterally, particularly in mass treatment. Cochrane (2) supports this treatment. But whatever sulfone is preferred, sufficient experience has now been gained to enable one to say that the complete answer to invasion by Hansen's bacillus has not been found. Hence a number of trials with an unrelated substance, thiosemicarbazone (TB-1), have now been carried out. Following the introduction of this substance for the treatment of leprosy by Hohener (3), a further account of successful treatment by Ryrie (4) induced us to undertake a trial among the patients at the leprosarium in Darwin, in the Northern Territory of Australia. The trial period was one year, commencing in November 1950 and ending in November 1951.
منابع مشابه
Comparison of diaminodiphenylsulfone and thiosemicarbazone in the treatment of lepromatous leprosy; clinical and bacteriological evaluation in sixty hospitalized patients.
The recent introduction of diaminodiphenylsulfone (DDS) and the thiosemicarbazones represents a significant contribution in the treatment of leprosy. The efficacy of DDS has been confirmed by a number of well-controlled observations (1, 2, 4, 5, 8, 10, 11). The effectiveness of thiosemicarbazone still remains to be evaluated (3, 7, 9, 12, 13, 14). For both drugs, the periods of observation have...
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ورودعنوان ژورنال:
- International journal of Leprosy
دوره 21 1 شماره
صفحات -
تاریخ انتشار 1953